NIR-propelled Janus nanomotors for active photoacoustic imaging and synergistic photothermal/chemodynamic therapy

Xiaolei Zhang; Chang Liu; Yangsai Lyu; Ningning Xing; Jia Li; Kun Song; Xiaohui Yan

doi:10.1016/j.jcis.2023.05.172

NIR-propelled Janus nanomotors for active photoacoustic imaging and synergistic photothermal/chemodynamic therapy

J Colloid Interface Sci. 2023 Oct 15:648:457-472. doi: 10.1016/j.jcis.2023.05.172. Epub 2023 May 29.

Authors

Xiaolei Zhang¹, Chang Liu², Yangsai Lyu³, Ningning Xing⁴, Jia Li⁵, Kun Song⁶, Xiaohui Yan⁷

Affiliations

¹ Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, China; School of Material Science and Engineering, University of Jinan, Jinan, China.
² Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, China; Gynecology oncology key laboratory, Qilu Hospital of Shandong University, Jinan, China.
³ Department of Mathematics and Statistics, Queen's University, Kingston, Canada.
⁴ School of Material Science and Engineering, University of Jinan, Jinan, China.
⁵ School of Material Science and Engineering, University of Jinan, Jinan, China. Electronic address: mse_lij@ujn.edu.cn.
⁶ Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, China; Gynecology oncology key laboratory, Qilu Hospital of Shandong University, Jinan, China. Electronic address: songkun2001226@sdu.edu.cn.
⁷ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Centre for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.

PMID: 37302229
DOI: 10.1016/j.jcis.2023.05.172

Abstract

Synthetic nanomotors have great application potential in deep tissue imaging and tumor treatment due to their active movement ability. Herein, a novel near infrared (NIR) light-driven Janus nanomotor is reported for active photoacoustic (PA) imaging and synergistic photothermal/chemodynamic therapy (PTT/CDT). Au nanoparticles (Au NPs) are sputtered on the half-sphere surface of copper-doped hollow cerium oxide nanoparticles after bovine serum albumin (BSA) modification. Such Janus nanomotors exhibit a rapid autonomous motion with a maximum speed of 110.6 ± 0.2 μm/s under 808 nm laser irradiation with a density of 3.0 W/cm². With the assistance of light-powered motion, the Au/Cu-CeO₂@BSA nanomotors (ACCB Janus NMs) can effectively adhere to and mechanically perforate tumor cells, thereby causing the higher cellular uptake and significantly enhancing the tumor tissue permeability in the tumor microenvironment (TME). ACCB Janus NMs also exhibit high nanozyme activity that can catalyze the production of reactive oxygen species (ROS) to reduce the TME oxidative stress response. Meanwhile, the potential PA imaging capability of ACCB Janus NMs offer promise for early diagnosis of tumors due to the photothermal conversion efficiency of Au NPs. Therefore, the nanotherapeutic platform provides a new tool for effectively imaging of deep tumors site in vivo to achieve synergistic PTT/CDT and accurate diagnosis.

Keywords: Accurate diagnosis; Janus nanomotors; NIR light-driven; PA imaging; PTT/CDT.

MeSH terms

Cell Line, Tumor
Gold / pharmacology
Gold / therapeutic use
Humans
Metal Nanoparticles*
Nanoparticles* / therapeutic use
Neoplasms* / drug therapy
Neoplasms* / therapy
Photoacoustic Techniques* / methods
Photothermal Therapy
Tumor Microenvironment

Substances

Gold