Clinical use of remdesivir in COVID-19 treatment: a retrospective cohort study

Abstract

Objectives: This study investigated remdesivir's clinical use to provide direct evidence of effectiveness for a low-middle income Asian setting.

Design: A one-to-one propensity score matching retrospective cohort study.

Setting: A tertiary hospital with COVID-19 treatment facilities in Vietnam.

Participants: A total of 310 patients in standard of care (SoC) group were matched with 310 patients in SoC+remdesivir (SoC+R) group.

Primary and secondary outcome measures: The primary outcome was time to critical progression, defined as all-cause mortality or critical illness. The secondary outcomes were length of oxygen therapy/ventilation and need for invasive mechanical ventilation. Outcome reports were presented as HR, OR or effect difference with 95% CI.

Results: Patients receiving remdesivir had a lower risk for mortality or critical illness (HR=0.68, 95% CI 0.47 to 0.96, p=0.030). Remdesivir was not associated with a shorter length of oxygen therapy/ventilation (effect difference -0.17 days, 95% CI -1.29 to 0.96, p=0.774). The need for invasive mechanical ventilation was lower in SoC+R group (OR=0.57, 95% CI 0.38 to 0.86, p=0.007).

Conclusions: This study's results showing remdesivir's benefits in non-critical patients with COVID-19 may be extrapolated to other similar low-middle income countries, allowing more regimens for limited resource areas and reducing poor outcomes and equity gap worldwide.

Keywords: CLINICAL PHARMACOLOGY; COVID-19; VIROLOGY.