Behavioural outcomes of children exposed to antidepressants and unmedicated depression during pregnancy

Francesca Anns; Karen E Waldie; Elizabeth R Peterson; Caroline Walker; Susan M B Morton; Stephanie D'Souza

doi:10.1016/j.jad.2023.05.097

Behavioural outcomes of children exposed to antidepressants and unmedicated depression during pregnancy

J Affect Disord. 2023 Oct 1:338:144-154. doi: 10.1016/j.jad.2023.05.097. Epub 2023 Jun 8.

Authors

Francesca Anns¹, Karen E Waldie², Elizabeth R Peterson², Caroline Walker³, Susan M B Morton⁴, Stephanie D'Souza⁵

Affiliations

¹ School of Psychology, The University of Auckland, Auckland, New Zealand; Centre of Methods and Policy Application in the Social Sciences, University of Auckland, Auckland, New Zealand.
² School of Psychology, The University of Auckland, Auckland, New Zealand; Centre for Longitudinal Research - He Ara ki Mua, The University of Auckland, Auckland, New Zealand.
³ Centre for Longitudinal Research - He Ara ki Mua, The University of Auckland, Auckland, New Zealand; School of Population Health, The University of Auckland, Auckland, New Zealand.
⁴ Centre for Longitudinal Research - He Ara ki Mua, The University of Auckland, Auckland, New Zealand; School of Population Health, The University of Auckland, Auckland, New Zealand; INSIGHT, University of Technology Sydney, Sydney, Australia.
⁵ Centre of Methods and Policy Application in the Social Sciences, University of Auckland, Auckland, New Zealand; School of Social Sciences, The University of Auckland, Auckland, New Zealand. Electronic address: s.dsouza@auckland.ac.nz.

PMID: 37295656
DOI: 10.1016/j.jad.2023.05.097

Abstract

Background: Antenatal exposure to both antidepressants and maternal depression has been associated with child behavioural difficulties. However, previous research has not adequately distinguished between the effects of the antidepressants and the underlying maternal depression.

Methods: Child behavioural difficulties were assessed using the Strengths and Difficulties Questionnaire at 2-, 4.5-, and 8-years of age by mothers in the Growing Up in New Zealand study (N = 6233 at 2-years; N = 6066 at 4.5-years; N = 4632 at 8-years). Mothers were classified as either on antidepressants, unmedicated depression, or neither based on self-reported antidepressant intake during pregnancy and the Edinburgh Postnatal Depression Scale. Hierarchical multiple logistic regressions were used to examine whether antenatal exposure to antidepressants and unmedicated depression had a differential association with child behavioural outcomes relative to no exposure.

Results: When later life depression in the mother and a range of birth and sociodemographic variables were accounted for, neither antenatal exposure to unmedicated depression or antidepressants remained associated with an increased risk of behavioural difficulties at the ages investigated. However, maternal later life depression was associated with behavioural difficulties in the fully adjusted analyses at all three ages investigated.

Limitations: The current study relied on mother-report of child behaviour which may be susceptible to bias due to maternal mental health problems.

Conclusions: Adjusted results did not show an adverse association between antenatal antidepressant exposure or unmedicated depression in relation to child behaviour. Findings also suggest that efforts to improve child behaviour need to include more family-based approaches that support maternal wellbeing.

Keywords: Antidepressants; Behavioural difficulties; Child behaviour; Maternal depression; Pregnancy; Unmedicated depression.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antidepressive Agents / adverse effects
Child
Child Behavior
Child, Preschool
Depression* / psychology
Female
Humans
Mothers / psychology
Parturition
Pregnancy
Pregnancy Complications* / chemically induced
Pregnancy Complications* / drug therapy
Pregnancy Complications* / epidemiology

Substances

Antidepressive Agents