Migrasomes released by HSV-2-infected cells serve as a conveyance for virus spread

Virol Sin. 2023 Aug;38(4):643-645. doi: 10.1016/j.virs.2023.06.001. Epub 2023 Jun 7.

¹ State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; Hubei Jiangxia Laboratory, Wuhan, 430200, China. Electronic address: liuyl@wh.iov.cn.
² State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.
³ State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
⁴ State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; Institute for Infection and Immunity, St George's University of London, London, SW17 0RE, UK. Electronic address: qhu@wh.iov.cn.

Abstract

•
Cells infected with HSV-2 release migrasomes containing HSV-2 virions.
•
HSV-2 in the isolated migrasomes can be transmitted to uninfected cells and cause productive infection.
•
It is the first time that migrasomes have been found to play a role in virus spread.