Zinc oxide nanoparticles (ZnONPs) have become the widely used metal oxide nanoparticles and drawn the interest of global researchers due to their biocompatibility, low toxicity, sustainability and cost-effective properties. Due to their unique optical and chemical properties, it emerges as a potential candidate in the fields of optical, electrical, food packaging and biomedical applications. Biological methods using green or natural routes are more environmentally friendly, simple and less use of hazardous techniques than chemical and/or physical methods in the long run. In addition, ZnONPs are less harmful and biodegradable while having the ability to greatly boost pharmacophore bioactivity. They play an important role in cell apoptosis because they enhance the generation of reactive oxygen species (ROS) and release zinc ions (Zn2+), causing cell death. Furthermore, these ZnONPs work well in conjunction with components that aid in wound healing and biosensing to track minute amounts of biomarkers connected to a variety of illnesses. Overall, the present review discusses the synthesis and most recent developments of ZnONPs from green sources including leaves, stems, bark, roots, fruits, flowers, bacteria, fungi, algae and protein, as well as put lights on their biomedical applications such as antimicrobial, antioxidant, antidiabetic, anticancer, anti-inflammatory, antiviral, wound healing, and drug delivery, and modes of action associated. Finally, the future perspectives of biosynthesized ZnONPs in research and biomedical applications are discussed.
Keywords: Biomedical applications; Mechanism of action; ROS generation; Zinc oxide nanoparticles.
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.