The cellular supply-side economics for phospholipids

Alvin C Y Kuk; David L Silver

doi:10.1016/j.cmet.2023.05.004

The cellular supply-side economics for phospholipids

Cell Metab. 2023 Jun 6;35(6):909-911. doi: 10.1016/j.cmet.2023.05.004.

Authors

Alvin C Y Kuk¹, David L Silver²

Affiliations

¹ Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857, Singapore.
² Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857, Singapore. Electronic address: david.silver@duke-nus.edu.sg.

PMID: 37285806
DOI: 10.1016/j.cmet.2023.05.004

Abstract

Choline is an essential nutrient, but how cells acquire it was not known. Two studies by Kenny et al. and Tsuchiya et al. identified the plasma membrane proteins FLVCR1 and FLVCR2 to be the bona fide choline transporters mediating choline uptake for de novo synthesis of phospholipids in all cells.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Humans
Phospholipids* / economics

Substances

Phospholipids