Versatile gold-silver-PB nanojujubes for multi-modal detection and photo-responsive elimination against bacteria

Xining Zhang; Youlin Xiong; Shuangfei Cai; Ting Wu; Zheng Lian; Chen Wang; Wei Zhang; Rong Yang

doi:10.3389/fchem.2023.1211523

Versatile gold-silver-PB nanojujubes for multi-modal detection and photo-responsive elimination against bacteria

Front Chem. 2023 May 22:11:1211523. doi: 10.3389/fchem.2023.1211523. eCollection 2023.

Authors

Xining Zhang^{1

2}, Youlin Xiong¹, Shuangfei Cai¹, Ting Wu¹, Zheng Lian¹, Chen Wang^{1

2}, Wei Zhang³, Rong Yang^{1

2}

Affiliations

¹ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Center of Materials Science and Optoelectronics Engineering, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, China.
² Sino-Danish College, Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing, China.
³ Institute of Applied Physics and Computational Mathematics, Beijing, China.

Abstract

Bacterial infections have become a serious threat to global public health. Nanomaterials have shown promise in the development of bacterial biosensing and antibiotic-free antibacterial modalities, but single-component materials are often less functional and difficult to achieve dual bacterial detection and killing. Herein, we report a novel strategy based on the effective integration of multi-modal bacterial detection and elimination, by constructing the versatile gold-silver-Prussian blue nanojujubes (GSP NJs) via a facile template etching method. Such incorporation of multi-components involves the utilization of cores of gold nanobipyramids with strong surface-enhanced Raman scattering (SERS) activity, the shells of Prussian blue as both an efficient bio-silent SERS label and an active peroxidase-mimic, and functionalization of polyvinyl pyrrolidone and vancomycin, respectively endowing them with good colloidal dispersibility and specificity against S. aureus. The GSP NJs show operational convenience in the SERS detection and excellent peroxidase-like activity for the sensitive colorimetric detection. Meanwhile, they exhibit robust near-infrared photothermal/photodynamic effects, and the photo-promoted Ag⁺ ions release, ultimately achieving a high antibacterial efficiency over 99.9% in 5 min. The NJs can also effectively eliminate complex biofilms. The work provides new insights into the design of multifunctional core-shell nanostructures for the integrated bacterial detection and therapy.

Keywords: SERS; bacterial detection; gold nanobipyramids; nanozyme; prussian blue; sterilization.

Grants and funding

This work is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB36000000), the National Key R&D Program of China (2021YFE0112600), and the National Natural Science Foundation of China (12174032).