Integra® Dermal Regeneration Template: From Design to Clinical Use

Philippe Taupin; Ankur Gandhi; Sunil Saini

doi:10.7759/cureus.38608

Integra® Dermal Regeneration Template: From Design to Clinical Use

Cureus. 2023 May 5;15(5):e38608. doi: 10.7759/cureus.38608. eCollection 2023 May.

Authors

Philippe Taupin¹, Ankur Gandhi², Sunil Saini²

Affiliations

¹ Medical Affairs, Integra LifeSciences, Princeton, USA.
² Research and Development, Integra LifeSciences, Princeton, USA.

Abstract

Integra^® Dermal Regeneration Template (IDRT, Integra LifeSciences, Princeton, NJ, USA) is a bilayer membrane developed, by Yannas and Burke in the 1980s, to fulfill the unmet need of surgeons having a readily available off-the-shelf dermal regeneration method. IDRT is composed of a sheet of porous cross-linked type I collagen and glycosaminoglycans, with a semi-permeable silicone sheet cover. IDRT is bio-engineered, from adult bovine Achilles tendons and chondroitin-6-sulfate derived from shark cartilage, in a multi-step process involving cross-linking using glutaraldehyde. By design, the composition, porosity, and biodegradation rate of IDRT guides the mechanism of wound repair towards a regenerative pathway. Its mechanism of action involves four distinct phases: imbibition, fibroblast migration, neovascularization, and remodeling/maturation. Originally developed for the post-excisional treatment of deep-partial to full-thickness burns where autograft is limited, over the years its use has expanded to reconstructive surgery.

Keywords: burn; collagen; dermal regeneration template; integra; trauma; wound reconstruction.

Publication types

Review

Grants and funding

Philippe Taupin and Sunil Saini are employees of, and receive salaries from, Integra LifeSciences Corporation. Ankur Gandhi was an employee of, and was receiving a salary from, Integra LifeSciences Corporation when the manuscript was written. Philippe Taupin, Sunil Saini, and Ankur Gandhi own shares of common stock of Integra LifeSciences Holdings Corporation.