Suppressors of the vestigial mutant phenotype increase the level of expression of the gene

Domenico Flagiello; Nadia Fellini; Christian Cibert; Alain Zider; Sandro Cavicchi; Joel Silber

doi:10.1046/j.1440-169X.1996.t01-4-00012.x

Suppressors of the vestigial mutant phenotype increase the level of expression of the gene

Dev Growth Differ. 1996 Oct;38(5):557-564. doi: 10.1046/j.1440-169X.1996.t01-4-00012.x.

Authors

Domenico Flagiello^{1

2}, Nadia Fellini², Christian Cibert¹, Alain Zider¹, Sandro Cavicchi², Joel Silber¹

Affiliations

¹ Institut Jacques Monod, Tour 43, 2 Place Jussieu, 75005 Paris, France.
² Departimento di Biologia evoluzionistica e sperimentale, Universita di Bologna, via Selmi 3, 40126 Bologna, Italy.

PMID: 37281251
DOI: 10.1046/j.1440-169X.1996.t01-4-00012.x

Abstract

Suppressor genes of the vestigial phenotype have been isolated in a wild-type population. These suppressors have an effect on different wing mutants and are allele-specific in the case of vestigial. In a vg^BG background they produced overgrowth of the imaginal wing disc. They also induce cell death in the wild-type strain and alter the distribution of cell death in the mutant strain. Expression of vestigial is increased in the wing disc only. Hypotheses formed to determine the nature of these suppressors are in favor of a direct interaction between these genes and vestigial.

Keywords: suppressor genes; tumor suppressors; vestigial.