Talaromyces rugulosus ventriculitis diagnosed by nanopore amplicon sequencing, 2022

Yoonkyung Lee; Narae Kim; Seungae Kim; Jiyeon Ha; Jangsup Moon; Kon Chu

doi:10.1016/j.jiac.2023.05.021

Talaromyces rugulosus ventriculitis diagnosed by nanopore amplicon sequencing, 2022

J Infect Chemother. 2023 Oct;29(10):985-987. doi: 10.1016/j.jiac.2023.05.021. Epub 2023 Jun 4.

Authors

Yoonkyung Lee¹, Narae Kim², Seungae Kim², Jiyeon Ha², Jangsup Moon³, Kon Chu⁴

Affiliations

¹ Department of Neurology, Laboratory for Neurotherapeutics, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, 03080, South Korea; Department of Neurology, Dong-A University Hospital, Busan, 49315, South Korea.
² Department of Neurology, Laboratory for Neurotherapeutics, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, 03080, South Korea.
³ Department of Neurology, Laboratory for Neurotherapeutics, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, 03080, South Korea; Department of Genomic Medicine, Seoul National University Hospital, Seoul, 03080, South Korea. Electronic address: jangsup.moon@gmail.com.
⁴ Department of Neurology, Laboratory for Neurotherapeutics, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, 03080, South Korea. Electronic address: stemcell.snu@gmail.com.

PMID: 37279804
DOI: 10.1016/j.jiac.2023.05.021

Abstract

Ventriculitis has serious complications and a high mortality rate, so it is important to early identification of the pathogen for appropriate treatment. We report case of ventriculitis caused by Talaromyces rugulosus, a rare pathogen, in South Korea. Affected patient was immunocompromised. Repeated cerebrospinal fluid culture tests were negative, but the pathogen was identified by fungal internal transcribed spacer amplicon nanopore sequencing. The pathogen was detected outside the endemic area of talaromycosis.

Keywords: CNS infection; Nanopore amplicon sequencing; Talaromyces rugulosus.

Copyright © 2023 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.

Publication types

Case Reports

MeSH terms

Cerebral Ventriculitis* / diagnosis
Cerebral Ventriculitis* / drug therapy
Humans
Mycoses* / diagnosis
Mycoses* / microbiology
Myelitis*
Nanopore Sequencing*
Nanopores*

Supplementary concepts

Talaromyces rugulosus