Chromatin-interacting RNA-binding proteins regulate transcription

Abstract

RNA-binding proteins (RBPs) are essential regulators involved in the fate determination of diverse RNA species; however, emerging evidence indicates that a subset of RBPs may physically interact with chromatin and function at the transcriptional level. Here, we highlight the recently discovered mechanisms of chromatin-interacting RBPs (ChRBPs) in the regulation of chromatin/transcriptional activities.

Keywords: RNA polymerase II; RNA-binding proteins; chromatin state; liquid–liquid phase separation; transcription factor; transcriptional regulation.