Parthanatos type programmed cell death and septic patient mortality

Abstract

Objective: Parthanatos is a form of programmed cell death mediated by apoptosis-inducing factor (AIF). However, there are not data on parthanatos in septic patients. The objective of the current study was to explore whether parthanatos is associated with mortality of septic patients.

Design: Observational and prospective study.

Setting: Three Spanish Intensive Care Units during 2017.

Patients: Patients with sepsis according to Sepsis-3 Consensus criteria.

Interventions: Serum AIF concentrations were determined at moment of sepsis diagnosis.

Main variable of interest: Mortality at 30 days.

Results: There were included 195 septic patients, and non-surviving (n=72) had serum AIF levels (p<0.001), lactic acid (p<0.001) and APACHE-II (p<0.001) that surviving (n=123). Multiple logistic regression analysis showed that patients with serum AIF levels>55.6ng/mL had higher mortality risk (OR=3.290; 95% CI=1.551-6.979; p=0.002) controlling for age, SOFA and lactic acid.

Conclusions: Parthanatos is associated with mortality of septic patients.

Keywords: Apoptosis-inducing factor; Factor inductor de apoptosis; Mortalidad; Mortality; Outcome; Parthanatos; Resultado; Sepsis.