Decoding the mechanisms of allostery

Saif Khan; Cornelius Gati

doi:10.7554/eLife.88749

Decoding the mechanisms of allostery

Elife. 2023 Jun 2:12:e88749. doi: 10.7554/eLife.88749.

Authors

Saif Khan¹, Cornelius Gati¹

Affiliation

¹ Bridge Institute, USC Michelson Center for Convergent Biosciences, Department of Biological Sciences, University of Southern California, Los Angeles, United States.

Abstract

A complex interplay between structure, conformational dynamics and pharmacology defines distant regulation of G protein-coupled receptors.

Keywords: allostery; biochemistry; chemical biology; drug discovery; molecular biophysics; molecular dynamics; molecular pharmacology; muscarinic acetylcholine receptors; none; structural biology.

Publication types

Editorial
Comment

MeSH terms

Allosteric Regulation
Molecular Conformation
Molecular Dynamics Simulation*
Receptors, G-Protein-Coupled*

Substances

Receptors, G-Protein-Coupled