Efomycine U, a new C2-asymmetric elaiophylin derivative from Streptomyces malaysiensis DSM 4137

Jing Xu; Jingwan Wu; Dongdong Zhou; Xuexia Zhang; Peter F Leadlay

doi:10.1080/14786419.2023.2214839

Efomycine U, a new C₂-asymmetric elaiophylin derivative from Streptomyces malaysiensis DSM 4137

Nat Prod Res. 2023 Jun 2:1-6. doi: 10.1080/14786419.2023.2214839. Online ahead of print.

Authors

Jing Xu^{1

2}, Jingwan Wu¹, Dongdong Zhou¹, Xuexia Zhang¹, Peter F Leadlay²

Affiliations

¹ Collaborative Innovation Center of Ecological Civilization, School of Chemical Engineering and Technology, Hainan University, Haikou, China.
² Department of Biochemistry, University of Cambridge, Cambridge, UK.

PMID: 37265103
DOI: 10.1080/14786419.2023.2214839

Abstract

Chemical examination of an actinomycete strain Streptomyces malaysiensis DSM 4137 derived from a soil sample derived isolate Streptomyces sp. DSM 3816, yielded a new C₂-asymmetric elaiophylin derivative efomycine U (1) and a known analogue halichoblelide D (2). These structures were unambiguously elucidated on the basis of extensive NMR spectroscopic and mass spectrometric analyses. All compounds isolated were subjected to antimicrobial, cytotoxic and immnosuppressive activities evaluation.

Keywords: Streptomyces malaysiensis; biological activities; efomycine U; structure identification.