Effect of blue light on the cell viability of A549 lung cancer cells and investigations into its possible mechanism

Abstract

Blue light has attracted extensive attention as a new potential cancer therapy. Recent studies have indicated that blue light has a significant inhibition effect on A459 cells. However, the effect of light parameters on the treatment of A549 cells and the mechanism of how blue light made the effect was still unclear. This study aimed to investigate A549 cells responses to blue light with varying irradiance and dose-dense, and tried to find out the mechanism of the effects blue light made. The results suggested that the responses of A549 cells to blue light with different irradiance and dose-dense were different and the decrease of cell viability reached saturation when the irradiance reached 3 mW/cm² and the dose-dense reached 3.6 J/cm² . It was assumed that blue light suppressed PI3K/AKT pathway and promoted the expression of JNK and p53 to affect the proliferation of A549 cells.

Keywords: A549; blue light; non-small-cell lung cancer; photobiomodulation.