Comprehensive characterization of a novel, oncogenic and targetable SEPTIN6::ABL2 fusion in T-ALL

Antonio Lahera; Laura Vela-Martín; Pilar López-Nieva; Rocío N Salgado; Sandra Rodríguez-Perales; Raúl Torres-Ruiz; José L López-Lorenzo; Javier Cornago; Pilar Llamas; Pablo Fernández-Navarro; Rebeca Sánchez-Domínguez; José C Segovia; Isabel Sastre; María Á Cobos-Fernández; Pablo Menéndez; Javier Santos; José Fernández-Piqueras; María Villa-Morales

doi:10.1111/bjh.18901

Comprehensive characterization of a novel, oncogenic and targetable SEPTIN6::ABL2 fusion in T-ALL

Br J Haematol. 2023 Aug;202(3):693-698. doi: 10.1111/bjh.18901. Epub 2023 Jun 2.

Authors

Antonio Lahera^{1

2

3}, Laura Vela-Martín^{1

2

3}, Pilar López-Nieva^{1

2

3

4}, Rocío N Salgado⁵, Sandra Rodríguez-Perales⁶, Raúl Torres-Ruiz^{6

7

8}, José L López-Lorenzo⁹, Javier Cornago⁹, Pilar Llamas⁹, Pablo Fernández-Navarro^{10

11}, Rebeca Sánchez-Domínguez^{7

8

12}, José C Segovia^{7

8

12}, Isabel Sastre², María Á Cobos-Fernández¹³, Pablo Menéndez^{14

15

16

17

18}, Javier Santos^{1

2

3

4}, José Fernández-Piqueras^{1

2

3

4}, María Villa-Morales^{1

2

3

4}

Affiliations

¹ Department of Biology, Universidad Autónoma de Madrid, Madrid, Spain.
² Department of Genome Dynamics and Function, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.
³ Area of Genetics and Genomics, IIS Fundación Jiménez Díaz, Madrid, Spain.
⁴ Institute for Molecular Biology-IUBM, Universidad Autónoma de Madrid, Madrid, Spain.
⁵ Cytogenetics Service, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
⁶ Molecular Cytogenetics & Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncologicas (CNIO), Madrid, Spain.
⁷ Division of Cell Technology, Biomedical Innovative Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
⁸ Advanced Therapy Unit, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD/UAM), Madrid, Spain.
⁹ Division of Hematology and Hemotherapy, IIS Fundación Jiménez Díaz, Madrid, Spain.
¹⁰ Unit of Cancer and Environmental Epidemiology, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, Spain.
¹¹ Networking Biomedical Research Centre of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
¹² Networking Biomedical Research Centre of Rare Diseases (CIBERER), Madrid, Spain.
¹³ Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
¹⁴ Josep Carreras Leukemia Research Institute, Barcelona, Spain.
¹⁵ Red Española de Terapias Avanzadas (TERAV)-Instituto de Salud Carlos III (ISCIII) (RICORS, RD21/0017/0029), Madrid, Spain.
¹⁶ CIBER-ONC, ISCIII, Barcelona, Spain.
¹⁷ Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
¹⁸ Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain.

PMID: 37264982
DOI: 10.1111/bjh.18901

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

DNA-Binding Proteins
Humans
Leukemia-Lymphoma, Adult T-Cell*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*
Protein-Tyrosine Kinases

Substances

DNA-Binding Proteins
Protein-Tyrosine Kinases