Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023

Mathilde Grapin; Audrey Mirand; Didier Pinquier; Aurélie Basset; Matthieu Bendavid; Maxime Bisseux; Marion Jeannoël; Bérengère Kireche; Manoelle Kossorotoff; Anne-Sophie L'Honneur; Lila Robin; Yves Ville; Sylvain Renolleau; Véronique Lemee; Pierre-Henri Jarreau; Isabelle Desguerre; Florence Lacaille; Marianne Leruez-Ville; Clémence Guillaume; Cécile Henquell; Alexandre Lapillonne; Isabelle Schuffenecker; Mélodie Aubart

doi:10.2807/1560-7917.ES.2023.28.22.2300253

Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023

Euro Surveill. 2023 Jun;28(22):2300253. doi: 10.2807/1560-7917.ES.2023.28.22.2300253.

Authors

Mathilde Grapin^{1

2}, Audrey Mirand^{2

3

4}, Didier Pinquier⁵, Aurélie Basset⁶, Matthieu Bendavid¹, Maxime Bisseux^{3

4}, Marion Jeannoël⁷, Bérengère Kireche⁸, Manoelle Kossorotoff⁹, Anne-Sophie L'Honneur¹⁰, Lila Robin⁸, Yves Ville¹¹, Sylvain Renolleau¹, Véronique Lemee¹², Pierre-Henri Jarreau⁶, Isabelle Desguerre⁹, Florence Lacaille¹³, Marianne Leruez-Ville¹⁴, Clémence Guillaume¹⁵, Cécile Henquell^{3

4}, Alexandre Lapillonne¹⁶, Isabelle Schuffenecker^{17

7}, Mélodie Aubart^{18

17

9}

Affiliations

¹ Paediatric Intensive Care Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
² These authors contributed equally to the work and share the first authorship.
³ Clermont-Ferrand University Hospital, 3IHP - Infection Inflammation et Interaction Hôtes Pathogènes Virology Department, French Reference Centre for enteroviruses and parechovirus, coordination laboratory, Clermont-Ferrand, France.
⁴ Auvergne University, LMGE UMR CNRS 6023, Team Epidemiology and pathophysiology of enterovirus Infection, Clermont-Ferrand, France.
⁵ Neonatal and Paediatric Intensive Care Units, Rouen University Hospital, Rouen, France.
⁶ Neonatal Intensive Care Unit, Cochin-Port Royal University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
⁷ Hospices Civils de Lyon, Virology Department, French Reference Centre for enteroviruses and parechoviruses, associated laboratory, Lyon, France.
⁸ Neonatal and Paediatric Intensive Care Units, Orléans Regional Hospital, Orléans, France.
⁹ Paediatric Neurology Department, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
¹⁰ Virology laboratory, Cochin University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
¹¹ Obstetrics and Fetal Medicine Department, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
¹² Virology Department, Rouen University Hospital, Rouen, France.
¹³ Pediatric Gastroenterology-Hepatology-Nutrition Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, University of Paris, Paris, France.
¹⁴ Clinical Microbiology laboratory and Virology unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
¹⁵ Orléans Hospital, Microbiology laboratory, Orléans, France.
¹⁶ Neonatal Intensive Care Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
¹⁷ These authors contributed equally to the work and share the last authorship.
¹⁸ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Imagine Institute, Institut National de la Santé et de la Recherche Médicale U1163, Paris, France.

PMID: 37261730
PMCID: PMC10236930
DOI: 10.2807/1560-7917.ES.2023.28.22.2300253

Abstract

We report nine severe neonatal infections caused by a new variant of echovirus 11. All were male, eight were twins. At illness onset, they were 3-5 days-old and had severe sepsis and liver failure. This new variant, detected in France since April 2022, is still circulating and has caused more fatal neonatal enterovirus infections in 2022 and 2023 (8/496; 1.6%, seven associated with echovirus 11) compared with 2016 to 2021 (7/1,774; 0.4%). National and international alerts are warranted.

Keywords: Echovirus-11; Enterovirus; liver failure; neonatal sepsis.

Publication types

Comment

MeSH terms

Communicable Diseases*
Echovirus Infections* / diagnosis
Echovirus Infections* / epidemiology
Enterovirus B, Human / genetics
Enterovirus Infections* / diagnosis
Enterovirus Infections* / epidemiology
Enterovirus*
Female
France / epidemiology
Humans
Infant, Newborn
Male