The role of mesenchymal stem cell-derived exosome in epigenetic modifications in inflammatory diseases

Zihan Zhao; Li Zhang; Dickson Kofi Wiredu Ocansey; Bo Wang; Fei Mao

doi:10.3389/fimmu.2023.1166536

The role of mesenchymal stem cell-derived exosome in epigenetic modifications in inflammatory diseases

Front Immunol. 2023 May 16:14:1166536. doi: 10.3389/fimmu.2023.1166536. eCollection 2023.

Authors

Zihan Zhao¹, Li Zhang², Dickson Kofi Wiredu Ocansey^{1

3}, Bo Wang¹, Fei Mao¹

Affiliations

¹ Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, China.
² Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.
³ Directorate of University Health Services, University of Cape Coast, Cape Coast, Ghana.

Abstract

Epigenetic modification is a complex process of reversible and heritable alterations in gene function, and the combination of epigenetic and metabolic alterations is recognized as an important causative factor in diseases such as inflammatory bowel disease (IBD), osteoarthritis (OA), systemic lupus erythematosus (SLE), and even tumors. Mesenchymal stem cell (MSC) and MSC-derived exosome (MSC-EXO) are widely studied in the treatment of inflammatory diseases, where they appear to be promising therapeutic agents, partly through the potent regulation of epigenetic modifications such as DNA methylation, acetylation, phosphorylation, and expression of regulatory non-coding RNAs, which affects the occurrence and development of inflammatory diseases. In this review, we summarize the current research on the role of MSC-EXO in inflammatory diseases through their modulation of epigenetic modifications and discuss its potential application in the treatment of inflammatory diseases.

Keywords: epigenetic modification; inflammatory bowel disease; mesenchymal stem cell-derived exosome; osteoarthritis; systemic lupus erythematosus.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

DNA Methylation
Epigenesis, Genetic
Exosomes* / metabolism
Humans
Lupus Erythematosus, Systemic* / metabolism
Mesenchymal Stem Cells* / metabolism

Grants and funding

National Natural Science Fund of China (Grant no.82250410378), the 2022 Jiangsu Excellent postdoctoral program (Grant no.2022ZB634), the open project of clinical medical research center of Gynecology and Traditional Chinese Medicine of Zhenjiang (Grant no. SS202204-KFC01), and Zhenjiang key research and development plan (social development) (Grant no.SH2022062; Grant no.SH2022091).