Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus Xylaria curta E10 and Their Cytotoxicity

Xian Zhang; Yinzhong Fan; Ke Ye; Xiaoyan Pan; Xujun Ma; Honglian Ai; Baobao Shi; Jikai Liu

doi:10.3390/ph16020193

Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus Xylaria curta E10 and Their Cytotoxicity

Pharmaceuticals (Basel). 2023 Jan 28;16(2):193. doi: 10.3390/ph16020193.

Authors

Xian Zhang^{1

2}, Yinzhong Fan¹, Ke Ye¹, Xiaoyan Pan¹, Xujun Ma¹, Honglian Ai^{1

2}, Baobao Shi^{1

2}, Jikai Liu^{1

2}

Affiliations

¹ School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
² State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

Abstract

Six previously undescribed cytochalasins, Curtachalasins X1-X6 (1-6), together with six known compounds (7-12) were isolated from the endophytic fungus Xylaria curta E10 harbored in the plant Solanum tuberosum. The structures were elucidated by the interpretation of HRESIMS, UV, and NMR data. The absolute configurations of Curtachalasins X1-X6 were determined by comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. In bioassays, Curtachalasin X1 (1) and X5 (5) showed cytotoxic activity against the MCF-7 cell line with IC₅₀ values of 2.03 μM and 0.85 μM, respectively.

Keywords: Xylaria curta; cytochalasins; cytotoxicity; endophyte fungus; isolation and structure elucidation.

Abstract

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