Regulation of inflammation in cancer by dietary eicosanoids

Haixia Yang; Eva Rothenberger; Tong Zhao; Wendong Fan; Abigail Kelly; Ahmed Attaya; Daidi Fan; Dipak Panigrahy; Jianjun Deng

doi:10.1016/j.pharmthera.2023.108455

Regulation of inflammation in cancer by dietary eicosanoids

Pharmacol Ther. 2023 Aug:248:108455. doi: 10.1016/j.pharmthera.2023.108455. Epub 2023 May 29.

Authors

Haixia Yang¹, Eva Rothenberger², Tong Zhao³, Wendong Fan³, Abigail Kelly², Ahmed Attaya², Daidi Fan⁴, Dipak Panigrahy⁵, Jianjun Deng⁶

Affiliations

¹ College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. Electronic address: hyang@cau.edu.cn.
² Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
³ College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
⁴ Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an 710069, China.
⁵ Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: dpanigra@bidmc.harvard.edu.
⁶ Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an 710069, China; State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address: dengjianjun@nwu.edu.cn.

PMID: 37257760
DOI: 10.1016/j.pharmthera.2023.108455

Abstract

Background: Cancer is a major burden of disease worldwide and increasing evidence shows that inflammation contributes to cancer development and progression. Eicosanoids are derived from dietary polyunsaturated fatty acids, such as arachidonic acid (AA), and are mainly produced by a series of enzymatic pathways that include cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P-450 epoxygenase (CYP). Eicosanoids consist of at least several hundred individual molecules and play important roles in the inflammatory response and inflammation-related cancers.

Scope and approach: Dietary sources of AA and biosynthesis of eicosanoids from AA through different metabolic pathways are summarized. The bioactivities of eicosanoids and their potential molecular mechanisms on inflammation and cancer are revealed. Additionally, current challenges and limitations in eicosanoid research on inflammation-related cancer are discussed.

Key findings and conclusions: Dietary AA generates a large variety of eicosanoids, including prostaglandins, thromboxane A2, leukotrienes, cysteinyl leukotrienes, lipoxins, hydroxyeicosatetraenoic acids (HETEs), and epoxyeicosatrienoic acids (EETs). Eicosanoids exert different bioactivities and mechanisms involved in the inflammation and related cancer developments. A deeper understanding of eicosanoid biology may be advantageous in cancer treatment and help to define cellular targets for further therapeutic development.

Keywords: Arachidonic acid; Cancer; Eicosanoids; Inflammation; Mechanisms.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Arachidonic Acid / metabolism
Cyclooxygenase 2
Eicosanoids* / metabolism
Humans
Inflammation / metabolism
Leukotrienes
Neoplasms* / metabolism

Substances

Eicosanoids
Arachidonic Acid
Leukotrienes
Cyclooxygenase 2