Helminth infections may trigger host innate and adaptive immune responses. Group 2 innate lymphoid cells (ILC2) are an important factor involved in type 2 immune responses, and produce a large number of T helper 2 cell (Th2) cytokines following stimulation by interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), which play a critical role in parasite clearance and tissue repair. Following helminth infections, autocrine factors, mast cells, enteric nervous system and Th2 cells have been recently found to be involved in regulation of ILC2. Unraveling the role of ILC2 in immune response against helminth infections is of great value for basic research and drug development. This review summarizes the research progress on ILC2 and its role in helminth infections.
［摘要］ 蠕虫感染会诱发宿主产生I古丨有及特异性免疫应答。2型固有淋巴细胞(group 2 innate lymphoid cells, ILC2)是2 型免疫反应的重要参与者, 在白细胞介素25(interleukin 25, L-25)、L-33和胸腺基质淋巴细胞生成素(thymic stromal lymphopoietin, TSLP)刺激下而产生大量辅助型T细胞2(T helper 2 cell, Th2)型细胞因子, 从而在清除寄生虫及组织修复中发 挥重要作用。近年来研究发现蠕虫感染后, ILC2自分泌因子、肥大细胞、肠道神经系统、Th2细胞等均参与ILC2调 控。探索ILC2在抗蠕虫免疫中发挥的作用极具基础研究与临床药物开发价值。木文就ILC2及其在蠕虫感染中的作用 进行综述。.
Keywords: Group 2 innate lymphoid cell; Helminth; Immune regulation.