Harnessing the power of Raman spectroscopic imaging for ophthalmology

Jing Li; Peirao Yan; Yong Li; Ming Han; Qi Zeng; Juan Li; Zhe Yu; Dongjie Zhang; Xueli Chen

doi:10.3389/fchem.2023.1211121

Harnessing the power of Raman spectroscopic imaging for ophthalmology

Front Chem. 2023 May 12:11:1211121. doi: 10.3389/fchem.2023.1211121. eCollection 2023.

Authors

Jing Li¹, Peirao Yan², Yong Li¹, Ming Han², Qi Zeng², Juan Li¹, Zhe Yu¹, Dongjie Zhang², Xueli Chen²

Affiliations

¹ Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, Shaanxi, China.
² Center for Biomedical-photonics and Molecular Imaging, Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.

Abstract

Eye diseases can cause great inconvenience to people's daily life; therefore, it is necessary to study the causes of ocular diseases and related physiological processes. Raman spectroscopic imaging (RSI) is a non-destructive, non-contact detection technique with the advantages of label-free, non-invasive and highly specific. Compared with other mature imaging technologies, RSI can provide real-time molecular information and high-resolution imaging at relatively low cost, making it very suitable for quantitative detection of biological molecules. RSI can reflect the overall situation of the sample, revealing the content distribution of the same substance in different areas of the sample. This review focuses on the recent advances in ophthalmology, with particular emphasis on the powerful use of RSI techniques, as well as its combination with other imaging techniques. Finally, we prospect the wider application and future potential of RSI approaches in ophthalmology.

Keywords: Raman spectroscopic imaging; lens; multimodality imaging; ophthalmology; retina.

Publication types

Review

Grants and funding

This study has been supported by the Xiʼan Science and Technology Plan Project of China (No. 22YXYJ0054), the Key Research and Development Program of Shaanxi (2021ZDLSF04-05), the Shaanxi Young Top-notch Talent Program, and the Fundamental Research Funds for Central Universities (QTZX22065).