Seeking a better understanding of the non-receptor tyrosine kinase, SRMS

Raghuveera Kumar Goel; Nayoung Kim; Kiven Erique Lukong

doi:10.1016/j.heliyon.2023.e16421

Seeking a better understanding of the non-receptor tyrosine kinase, SRMS

Heliyon. 2023 May 20;9(6):e16421. doi: 10.1016/j.heliyon.2023.e16421. eCollection 2023 Jun.

Authors

Raghuveera Kumar Goel^{1

2}, Nayoung Kim³, Kiven Erique Lukong³

Affiliations

¹ Center for Network Systems Biology, Boston University, Boston, MA, USA.
² Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.
³ Department of Biochemistry, Microbiology, and Immunology, 107 Wiggins Road, Health Sciences Building, University of Saskatchewan, Saskatoon S7N 5E5, Saskatchewan, Canada.

Abstract

SRMS (Src-Related kinase lacking C-terminal regulatory tyrosine and N-terminal Myristoylation Sites) is a non-receptor tyrosine kinase first reported in a 1994 screen for genes regulating murine neural precursor cells. SRMS, pronounced "Shrims", lacks the C-terminal regulatory tyrosine critical for the regulation of the enzymatic activity of Src-family kinases (SFKs). Another remarkable characteristic of SRMS is its localization into distinct SRMS cytoplasmic punctae (SCPs) or GREL (Goel Raghuveera-Erique Lukong) bodies, a pattern not observed in the SFKs. This unique subcellular localization of SRMS could dictate its cellular targets, proteome, and potentially, substrates. However, the function of SRMS is still relatively unknown. Further, how is its activity regulated and by what cellular targets? Studies have emerged highlighting the potential role of SRMS in autophagy and in regulating the activation of BRK/PTK6. Potential novel cellular substrates have also been identified, including DOK1, vimentin, Sam68, FBKP51, and OTUB1. Recent studies have also demonstrated the potential role of the kinase in various cancers, including gastric and colorectal cancers and platinum resistance in ovarian cancer. This review discusses the advancements made in SRMS-related biology to date and the path to understanding the cellular and physiological significance of the kinase.

Keywords: BFKs; BRK; Breast cancer; DOK1; FRK; Kinase; Myristoylation; PTK70; SH2; SH3; SRMS; Signal transduction; Src; Tyrosine.

Publication types

Review