Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer

Kuang He; Wen-Juan Gan

doi:10.2147/CMAR.S411168

Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer

Cancer Manag Res. 2023 May 23:15:435-448. doi: 10.2147/CMAR.S411168. eCollection 2023.

Authors

Kuang He¹, Wen-Juan Gan¹

Affiliation

¹ Department of Pathology, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, Jiangsu, People's Republic of China.

Abstract

The Wnt/β-catenin signaling pathway is a growth control pathway involved in various biological processes as well as the development and progression of cancer. Colorectal cancer (CRC) is one of the most common malignancies in the world. The hyperactivation of Wnt signaling is observed in almost all CRC and plays a crucial role in cancer-related processes such as cancer stem cell (CSC) propagation, angiogenesis, epithelial-mesenchymal transition (EMT), chemoresistance, and metastasis. This review will discuss how the Wnt/β-catenin signaling pathway is involved in the carcinogenesis and progression of CRC and related therapeutic approaches.

Keywords: APC; CRC therapy; Wnt pathway; colorectal carcinogenesis.

Publication types

Review