Coaxial microfluidic spinning design produced high strength alginate membranes for antibacterial activity and drug release

Ying Zhang; Ting-Ting Li; Zhike Wang; Bing-Chiuan Shiu; Jia-Horng Lin; Ching-Wen Lou

doi:10.1016/j.ijbiomac.2023.124956

Coaxial microfluidic spinning design produced high strength alginate membranes for antibacterial activity and drug release

Int J Biol Macromol. 2023 Jul 15:243:124956. doi: 10.1016/j.ijbiomac.2023.124956. Epub 2023 May 26.

Authors

Ying Zhang¹, Ting-Ting Li², Zhike Wang¹, Bing-Chiuan Shiu³, Jia-Horng Lin⁴, Ching-Wen Lou⁵

Affiliations

¹ Innovation Platform of Intelligent and Energy-Saving Textiles, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China.
² Innovation Platform of Intelligent and Energy-Saving Textiles, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China; Tianjin and Education Ministry Key Laboratory of Advanced Textile Composite Materials, Tiangong University, Tianjin 300387, China. Electronic address: tingtingli@tiangong.edu.cn.
³ College of Material and Chemical Engineering, Minjiang University, Fuzhou 350108, China; Fujian Key Laboratory of Novel Functional Fibers and Materials, Minjiang University, Fuzhou, Fujian 350108, China.
⁴ Innovation Platform of Intelligent and Energy-Saving Textiles, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China; College of Material and Chemical Engineering, Minjiang University, Fuzhou 350108, China; Advanced Medical Care and Protection Technology Research Center, Department of Fiber and Composite Materials, Feng Chia University, Taichung City 407102, Taiwan; School of Chinese Medicine, China Medical University, Taichung City 404333, Taiwan.
⁵ Innovation Platform of Intelligent and Energy-Saving Textiles, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China; Fujian Key Laboratory of Novel Functional Fibers and Materials, Minjiang University, Fuzhou, Fujian 350108, China; Department of Bioinformatics and Medical Engineering, Asia University, Taichung City 413305, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung City 404333, Taiwan. Electronic address: cwlou@asia.edu.tw.

PMID: 37245751
DOI: 10.1016/j.ijbiomac.2023.124956

Abstract

Directional drug delivery and sufficient strength are two conditions that need to be met for wound dressing. In this paper, an oriented fibrous alginate membrane with sufficient strength was constructed via coaxial microfluidic spinning, and zeolitic imidazolate framework-8/ascorbic acid was used to realize drug delivery and antibacterial activity. The effects of the process parameters of the coaxial microfluidic spinning on the mechanical properties of the alginate membrane were discussed. In addition, it was found that the antimicrobial activity mechanism of zeolitic imidazolate framework-8 was attributed to the disruptive effect of reactive oxygen species (ROS) on bacteria, and the quantitative amount of generated ROS were evaluated by detecting •OH and H₂O₂. Furthermore, a mathematical drug diffusion model was established and showed high consistency with the experimental data (R² = 0.99). This study provides a new idea for the preparation of dressing materials with high strength and directional drug delivery and also provides some guidance for the development of coaxial microfluidic spin technology to be used in functional materials for drug release.

Keywords: Alginate membrane; Antimicrobial properties; Coaxial microfluidic spinning; Drug release model; Mechanical property; Zeolitic Imidazolate Framework-8.

MeSH terms

Alginates*
Anti-Bacterial Agents / pharmacology
Drug Liberation
Hydrogen Peroxide
Microfluidics*
Reactive Oxygen Species

Substances

Alginates
Reactive Oxygen Species
Hydrogen Peroxide
Anti-Bacterial Agents