Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure

Apoptosis. 2023 Aug;28(7-8):1226-1240. doi: 10.1007/s10495-023-01856-y. Epub 2023 May 27.

Abstract

This study investigated whether G3BP1 could regulate ferroptosis in hepatocytes during ALF by affecting the entry of P53 into the nucleus. Promoting G3BP1 expression could inhibit P53 entry by binding to the nuclear localization sequence of P53. The inhibition of SLC7A11 transcription was weakened after blocking of P53 binding to the promoter region of the SLC7A11 gene. The SLC7A11-GSH-GPX4 antiferroptotic pathway was subsequently activated, and the level of ferroptosis in ALF hepatocytes was inhibited.

Keywords: Acute liver failure; Ferroptosis; G3BP1; Nuclear localization; P53.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis
  • DNA Helicases
  • Ferroptosis* / genetics
  • Humans
  • Liver Failure, Acute*
  • Poly-ADP-Ribose Binding Proteins
  • RNA Helicases
  • RNA Recognition Motif Proteins
  • Tumor Suppressor Protein p53 / genetics

Substances

  • DNA Helicases
  • Tumor Suppressor Protein p53
  • Poly-ADP-Ribose Binding Proteins
  • RNA Helicases
  • RNA Recognition Motif Proteins
  • G3BP1 protein, human