Pre- and Postoperative Exercise Effectiveness in Mobility, Hemostatic Balance, and Prognostic Biomarkers in Hip Fracture Patients: A Study Protocol for a Randomized Controlled Trial

Biomedicines. 2023 Apr 24;11(5):1263. doi: 10.3390/biomedicines11051263.

Abstract

Hip fractures are a major health concern, particularly for older adults, as they can reduce life quality, mobility loss, and even death. Current evidence reveals that early intervention is recommended for endurance in patients with hip fractures. To our knowledge, preoperative exercise intervention in patients with hip fractures remains poorly researched, and no study has yet applied aerobic exercise preoperatively. This study aims to investigate the short-term benefits of a supervised preoperative aerobic moderate-intensity interval training (MIIT) program and the added effect of an 8-week postoperative MIIT aerobic exercise program with a portable upper extremity cycle ergometer. The work-to-recovery ratio will be 1-to-1, consisting of 120 s for each bout and four and eight rounds for the pre- and postoperative programs, respectively. The preoperative program will be delivered twice a day. A parallel group, single-blinded, randomized controlled trial (RCT) was planned to be conducted with 58 patients each in the intervention and control groups. This study has two primary purposes. First, to study the effect of a preoperative aerobic exercise program with a portable upper extremity cycle ergometer on immediate postoperative mobility. Second, to investigate the additional effect of an 8-week postoperative aerobic exercise program with a portable upper extremity cycle ergometer on the walking distance at eight weeks after surgery. This study also has several secondary objectives, such as ameliorating surgical and keeping hemostatic balance throughout exercise. This study may expand our knowledge of preoperative exercise effectiveness in hip fracture patients and enhance the current literature about early intervention benefits.

Keywords: coagulation; exercise therapy; fibrinolysis; hip fracture; physiotherapy; prehabilitation; rehabilitation; rotational thromboelastometry.

Grants and funding

This research was funded indirectly by the Stavros Niarchos Foundation (SNF). The Sports Excellence Center (1st Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, Greece) is supported exclusively by a donation from the SNF. The SNF has no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the protocol or the manuscript or decision to submit the protocol or the manuscript for publication.