9-O Acetylated Gangliosides in Health and Disease

Luis Vicente Herrera-Marcos; Dil Sahali; Mario Ollero

doi:10.3390/biom13050827

9-O Acetylated Gangliosides in Health and Disease

Biomolecules. 2023 May 12;13(5):827. doi: 10.3390/biom13050827.

Authors

Luis Vicente Herrera-Marcos¹, Dil Sahali^{1

2}, Mario Ollero¹

Affiliations

¹ Univ Paris Est Creteil, INSERM, IMRB, F-94010 Creteil, France.
² AP-HP, Hôpitaux Universitaires Henri Mondor, Service de Néphrologie, F-94010 Creteil, France.

Abstract

Glycosphingolipids comprise a lipid class characterized by the presence of sugar moieties attached to a ceramide backbone. The role of glycosphingolipids in pathophysiology has gained relevance in recent years in parallel with the development of analytical technologies. Within this vast family of molecules, gangliosides modified by acetylation represent a minority. Described for the first time in the 1980s, their relation to pathologies has resulted in increased interest in their function in normal and diseased cells. This review presents the state of the art on 9-O acetylated gangliosides and their link to cellular disorders.

Keywords: acetylation; cancer; glycosphingolipid; sialic acid; sphingolipid.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acetylation
Gangliosides*
Glycosphingolipids*

Substances

Gangliosides
Glycosphingolipids

Grants and funding

Luis V Herrera-Marcos’s contract has been funded by the European Union’s NextGenerationEU budget through the Spanish University Ministry program Margarita Salas.