Intracellular signaling mechanisms that shape postsynaptic GABAergic synapses

Hyeji Jung; Seungjoon Kim; Jaewon Ko; Ji Won Um

doi:10.1016/j.conb.2023.102728

Intracellular signaling mechanisms that shape postsynaptic GABAergic synapses

Curr Opin Neurobiol. 2023 Aug:81:102728. doi: 10.1016/j.conb.2023.102728. Epub 2023 May 24.

Authors

Hyeji Jung¹, Seungjoon Kim², Jaewon Ko², Ji Won Um³

Affiliations

¹ Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, South Korea.
² Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, South Korea; Center for Synapse Diversity and Specificity, DGIST, 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, South Korea.
³ Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, South Korea; Center for Synapse Diversity and Specificity, DGIST, 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu 42988, South Korea. Electronic address: jiwonum@dgist.ac.kr.

PMID: 37236068
DOI: 10.1016/j.conb.2023.102728

Abstract

Postsynaptic GABAergic receptors interact with various membrane and intracellular proteins to mediate inhibitory synaptic transmission. They form structural and/or signaling synaptic protein complexes that perform a variety of postsynaptic functions. In particular, the key GABAergic synaptic scaffold, gephyrin, and its interacting partners govern downstream signaling pathways that are essential for GABAergic synapse development, transmission, and plasticity. In this review, we discuss recent researches on GABAergic synaptic signaling pathways. We also outline the main outstanding issues that need to be addressed in this field and highlight the association of dysregulated GABAergic synaptic signaling with the onset of various brain disorders.

Keywords: Brain disorders; GABA; GABAergic signaling; GABAergic synapse; Gephyrin.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carrier Proteins / metabolism
Neuronal Plasticity / physiology
Receptors, GABA-A* / metabolism
Synapses* / physiology
Synaptic Transmission / physiology

Substances

Receptors, GABA-A
Carrier Proteins