Crosstalk between cholesterol metabolism and psoriatic inflammation

Front Immunol. 2023 May 10:14:1124786. doi: 10.3389/fimmu.2023.1124786. eCollection 2023.

Abstract

Psoriasis is a chronic autoinflammatory skin disease associated with multiple comorbidities, with a prevalence ranging from 2 to 3% in the general population. Decades of preclinical and clinical studies have revealed that alterations in cholesterol and lipid metabolism are strongly associated with psoriasis. Cytokines (tumor necrosis factor-α (TNF-α), interleukin (IL)-17), which are important in the pathogenesis of psoriasis, have been shown to affect cholesterol and lipid metabolism. Cholesterol metabolites and metabolic enzymes, on the other hand, influence not only the biofunction of keratinocytes (a primary type of cell in the epidermis) in psoriasis, but also the immune response and inflammation. However, the relationship between cholesterol metabolism and psoriasis has not been thoroughly reviewed. This review mainly focuses on cholesterol metabolism disturbances in psoriasis and their crosstalk with psoriatic inflammation.

Keywords: cholesterol metabolism; immunity; immunometabolism; inflammation; psoriatic inflammation.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cholesterol
  • Cytokines* / metabolism
  • Humans
  • Inflammation
  • Lipid Metabolism
  • Psoriasis*

Substances

  • Cytokines
  • Cholesterol

Grants and funding

This research was supportedby CAMS Innovation Fund for Medical Sciences (CIFMS) (grant number: 2021-I2M-1-001, 2021-I2M-1-018, 2021-I2M-1-059), the Special Research Fund for Central Universities, Peking Union Medical College (grant number: 3332022156) and the Natural Science Foundation of Jiangsu province (grant numbers: BK20211027).