Morphologic spectrum of the epithelial tumors of the male and female urethra

Virchows Arch. 2023 Dec;483(6):751-764. doi: 10.1007/s00428-023-03565-y. Epub 2023 May 26.

Abstract

The classification of the epithelial tumors of the male and female urethra includes benign and malignant neoplasms. Primary urethral carcinomas and adenocarcinomas of the accessory glands are the most relevant tumors, both from the morphologic and clinical point of view. An accurate diagnosis, grading and staging are essential for determining adequate treatment strategies and outcome. Information on anatomy and histology of the urethra is of fundamental importance in understanding the morphology of the tumors, including the clinical importance of their location and origin.

Keywords: Accessory glans carcinoma; Clear cell adenocarcinoma; Conventional adenocarcinoma; Squamous cell carcinoma; Urethra; Urothelial carcinoma.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma* / diagnosis
  • Adenocarcinoma* / pathology
  • Biomarkers, Tumor
  • Female
  • Humans
  • Male
  • Urethra / pathology
  • Urethral Neoplasms* / diagnosis
  • Urethral Neoplasms* / pathology

Substances

  • Biomarkers, Tumor