Decision-making impairment under ambiguity but not under risk may underlie medication overuse in patients with chronic migraine

Chi Ieong Lau; Wei-Hung Chen; Han-Cheng Wang; Vincent Walsh

doi:10.1111/head.14513

Decision-making impairment under ambiguity but not under risk may underlie medication overuse in patients with chronic migraine

Headache. 2023 Jun;63(6):822-833. doi: 10.1111/head.14513. Epub 2023 May 26.

Authors

Chi Ieong Lau^{1

2

3

4

5}, Wei-Hung Chen^{1

6}, Han-Cheng Wang^{1

7}, Vincent Walsh²

Affiliations

¹ Dementia Center, Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
² Applied Cognitive Neuroscience Group, Institute of Cognitive Neuroscience, University College London, London, UK.
³ Institute of Biophotonics, National Yang Ming Chiao Tung University, Taipei, Taiwan.
⁴ College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
⁵ Department of Medicine, University Hospital, Taipa, Macau.
⁶ College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁷ College of Medicine, National Taiwan University, Taipei, Taiwan.

PMID: 37232343
DOI: 10.1111/head.14513

Abstract

Objective: To explore whether patients with chronic migraine and medication overuse headache (CM + MOH) present with decision-making deficit.

Background: Factors underlying MOH in patients with CM remain unclear. Whether the process of decision-making plays a role in MOH is still controversial. Decision-making varies in the degree of uncertainty: under ambiguity where the probability of outcome is unknown, and under risk where probabilities are known.

Methods: Decisions under ambiguity and risk were assessed with the Iowa Gambling Task and the Cambridge Gambling Task, respectively, whereas executive function was assessed by the Wisconsin Card Sorting Test.

Results: A total of 75 participants: 25 patients with CM + MOH, 25 with CM, and 25 age- and sex-similar healthy controls (HCs), completed this cross-sectional study. There was no significant difference in headache profiles except for more frequent analgesic use (mean ± SD: 23.5 ± 7.6 vs. 6.8 ± 3.4 days; p < 0.001) and higher Severity of Dependence Scores (median [25th-75th percentile]: 8 [5-11] vs. 1 [0-4]; p < 0.001) in patients with CM + MOH compared to CM. Total net score (mean ± SD) on the Iowa Gambling Task in patients with CM + MOH, CM, and HCs were - 8.1 ± 28.7, 10.9 ± 29.6, and 14.2 ± 28.8, respectively. There was a significant difference between the three groups (F_{(2, 72)} = 4.28, p = 0.017), with patients with CM + MOH making significantly more disadvantageous decisions than patients with CM (p = 0.024) and HCs (p = 0.008), while the CM and HC groups did not differ (p = 0.690). By contrast, there was no significant difference between the groups in the Cambridge Gambling Task and the Wisconsin Card Sorting Test. Furthermore, performance on the Iowa Gambling Task was inversely correlated with analgesic consumption (r = -0.41, p = 0.003), suggesting that decision-making under ambiguity may be related to MOH.

Conclusions: Our data suggest that patients with CM + MOH had impaired decisions under ambiguous, but not risky situations. This dissociation indicates disrupted emotional feedback processing rather than executive dysfunction, which may underlie the pathogenesis of MOH.

Keywords: Cambridge Gambling Task; Iowa Gambling Task; chronic migraine; decision-making; medication overuse headache.

MeSH terms

Cross-Sectional Studies
Decision Making*
Humans
Migraine Disorders*
Neuropsychological Tests
Prescription Drug Overuse
Risk-Taking

Abstract

MeSH terms

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