Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models

Alfonso Varela-López; José M Romero-Márquez; María D Navarro-Hortal; César L Ramirez-Tortosa; Maurizio Battino; Tamara Y Forbes-Hernández; José L Quiles

doi:10.1016/j.exger.2023.112221

Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models

Exp Gerontol. 2023 Jul:178:112221. doi: 10.1016/j.exger.2023.112221. Epub 2023 May 31.

Authors

Alfonso Varela-López¹, José M Romero-Márquez¹, María D Navarro-Hortal¹, César L Ramirez-Tortosa², Maurizio Battino³, Tamara Y Forbes-Hernández¹, José L Quiles⁴

Affiliations

¹ Department of Physiology, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, University of Granada, Avda del Conocimiento s/n, Parque Tecnologico de la Salud, Armilla, Granada 18016, Spain.
² UGC de Anatomía Patológica Hospital San Cecilio de Granada, Granada, Spain.
³ Department of Clinical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy; International Joint Research Laboratory of Intelligent Agriculture and Agri-products Processing, Jiangsu University, Zhenjiang 212013, China.
⁴ Department of Physiology, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, University of Granada, Avda del Conocimiento s/n, Parque Tecnologico de la Salud, Armilla, Granada 18016, Spain; Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres, 21, 39011 Santander, Spain; Research and Development Functional Food Centre (CIDAF), Health Science Technological Park, Avenida del Conocimiento 37, 18016 Granada, Spain. Electronic address: jlquiles@ugr.es.

PMID: 37230336
DOI: 10.1016/j.exger.2023.112221

Abstract

The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of all age-associated chronic disorders can be delayed because these pathologies share age as primary underlying risk factor. One of the most extended ideas is that aging is consequence of the accumulation of molecular damage. According to the oxidative damage theory, antioxidants should slow down aging, extending lifespan and healthspan. The present review analyzes studies evaluating the effect of dietary antioxidants on lifespan of different aging models and discusses the evidence on favor of their antioxidant activity as anti-aging mechanisms. Moreover, possible causes for differences between the reported results are evaluated.

Keywords: Ageing; Aging; Bioactive compounds; Hormesis; Longevity; Nutrient-sensing pathways.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants* / pharmacology
Diet
Genotype
Longevity* / genetics
Models, Theoretical

Substances

Antioxidants