Endogenous NO-release multi-responsive hollow mesoporous silica nanoparticles for drug encapsulation and delivery

Shu Wu; Jinjing Shi; Xia Chen; Lu Bai; Qiuhua Wu; Guolin Zhang

doi:10.1016/j.colsurfb.2023.113346

Endogenous NO-release multi-responsive hollow mesoporous silica nanoparticles for drug encapsulation and delivery

Colloids Surf B Biointerfaces. 2023 Jul:227:113346. doi: 10.1016/j.colsurfb.2023.113346. Epub 2023 May 12.

Authors

Shu Wu¹, Jinjing Shi¹, Xia Chen¹, Lu Bai¹, Qiuhua Wu², Guolin Zhang³

Affiliations

¹ Liaoning Provincial Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials (Liaoning University), College of Chemistry, Liaoning University, Shenyang 110036, China.
² Liaoning Provincial Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials (Liaoning University), College of Chemistry, Liaoning University, Shenyang 110036, China. Electronic address: qiuhuawu@sina.com.
³ Liaoning Provincial Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials (Liaoning University), College of Chemistry, Liaoning University, Shenyang 110036, China. Electronic address: glzhang@lnu.edu.cn.

PMID: 37230051
DOI: 10.1016/j.colsurfb.2023.113346

Abstract

Novel multi-responsive drug delivery vehicles (CDs/PNVCL@HMSNs) were prepared by grafting amino-terminated poly (N-vinyl caprolactam) (PNVCL-NH₂) and amino-rich carbon dots (CDs) on the surface of aldehyde-functionalized HMSNs (HMSNs-CHO) via Schiff base reaction. The CDs were prepared from L-arginine and their surfaces were rich in guanidine. Doxorubicin (DOX) was loaded into the nanoparticles to form drug loaded vehicles (CDs/PNVCL@HMSNs-DOX) and the drug loading efficiency was 58.38%. The drug release behaviors of CDs/PNVCL@HMSNs-DOX showed temperature and pH responsiveness due to the poly (N-vinyl caprolactam) (PNVCL) and Schiff base bond. The high concentration of NO released in high concentration H₂O₂ of tumor site could induce tumor cells apoptosis. The multi-responsive CDs/PNVCL@HMSNs are intriguing drug carriers, which combine drug delivery and NO release in one.

Keywords: Carbon dots; Drug delivery; Endogenous NO-release; Hollow mesoporous silica nanoparticles; Multi-responsive.

MeSH terms

Caprolactam*
Doxorubicin / chemistry
Doxorubicin / pharmacology
Drug Carriers / chemistry
Drug Delivery Systems
Drug Liberation
Hydrogen Peroxide
Nanoparticles* / chemistry
Porosity
Schiff Bases
Silicon Dioxide / chemistry

Substances

Silicon Dioxide
Caprolactam
Hydrogen Peroxide
Schiff Bases
Doxorubicin
Drug Carriers