Objectives: Our objective was to develop and implement a system to solve the problems that students have as a result of few opportunities for consultation and hands-on exercise in nursing practice teaching, including an inability to participate in the whole process of patients' treatment and nursing, and lack of humanistic care for patients. Methods: The application of the system was conducted among undergraduate nursing students. In 2020, we cooperated with companies and jointly developed a virtual reality (VR) simulation of rehabilitation nursing for patients with cervical spondylosis (CS) and applied it to undergraduate nursing students. Results:The cumulative online training time of 79 students was (30.52±16.28) minutes/person and the average number of learning times was (3.12±1.78) times/person. Overall, 97.5% of the students rated the system as excellent. Conclusions: In thi s paper, we introduce the design, system construction, teaching design, and preliminary application effects of the system. In addition, we discuss the advantages, characteristics, limitations and countermeasures of the system, to provide reference for the construction of VR simulation experimental teaching courses for undergraduate nursing students under the background of new medical science.