Cellular drug delivery system for disease treatment

Luyue Wang; Yu Zhang; Yukun Ma; Yujia Zhai; Jianbo Ji; Xiaoye Yang; Guangxi Zhai

doi:10.1016/j.ijpharm.2023.123069

Cellular drug delivery system for disease treatment

Int J Pharm. 2023 Jun 25:641:123069. doi: 10.1016/j.ijpharm.2023.123069. Epub 2023 May 22.

Authors

Luyue Wang¹, Yu Zhang¹, Yukun Ma², Yujia Zhai³, Jianbo Ji⁴, Xiaoye Yang⁵, Guangxi Zhai⁶

Affiliations

¹ Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, PR China.
² Department of Pharmacy, Jinan Stomatologic Hospital, Jinan, Shandong 250001, PR China.
³ Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84124, USA.
⁴ Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, PR China. Electronic address: jijianbo@sdu.edu.cn.
⁵ Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, PR China. Electronic address: yangxiaoye@sdu.edu.cn.
⁶ Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, PR China. Electronic address: professorgxzhai@126.com.

PMID: 37225024
DOI: 10.1016/j.ijpharm.2023.123069

Abstract

The application of variable novel drug delivery system has shown a flowering trend in recent years. Among them, the cell-based drug delivery system (DDS) utilizes the unique physiological function of cells to deliver drugs to the lesion area, which is the most complex and intelligent DDS at present. Compared with the traditional DDS, the cell-based DDS has the potential of prolonged circulation in body. Cellular DDS is expected to be the best carrier to realize multifunctional drug delivery. This paper introduces and analyzes common cellular DDSs such as blood cells, immune cells, stem cells, tumor cells and bacteria as well as relevant research examples in recent years. We hope that this review can provide a reference for future research on cell vectors and promote the innovative development and clinical transformation of cell-based DDS.

Keywords: Cell carrier; Cell engineering; Cell therapy; Cellular drug delivery; Nanoparticles.

Publication types

Review

MeSH terms

Drug Delivery Systems*