In the current study, chitosan, poly (N-vinyl-2-pyrolidone) and polyamidoamine based hydrogels were prepared by Solution Casting Method using different quantity of graphene oxide (GO) for controlled cephradine (CPD) release. The hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction, thermal analysis, scanning electron microscope and atomic force microscopy. FTIR results endorsed the presence of particular functionalities and developed interfaces in hydrogels. The thermal stability was directly proportional to the amount of GO. Antibacterial activity was investigated against gram-negative bacteria resultantly; CAD-2 exhibited maximum bactericidal activity against Escherichia coli and Psuedomonas aeruginosa. In addition, in-vitro biodegradation was examined in phosphate buffer saline solution and proteinase K for 21 and 07 days respectively. The maximum swelling was exhibited by CAD-133777 % in distilled water that was governed by quasi-Fickian diffusion. The swelling volumes were inversely proportional to the amount of GO. In the same way, pH sensitive CPD release was detected by UV visible spectrophotometer that followed zero order and Higuchi models. However, in 4 h, 89.4 % and 83.7 % of CPD was released in PBS and SIF solution correspondingly. Therefore, the chitosan-based biocompatible and biodegradable hydrogel platforms offered substantial potential for the controlled CPD release in medico-biological applications.
Keywords: Cephradine release; Chitosan; Dendrimeric hydrogels; Graphene oxide; Polyamidoamine; pH sensitivity.
Copyright © 2023 Elsevier B.V. All rights reserved.