Biomedical applications of magnetosomes: State of the art and perspectives

Gang Ren; Xia Zhou; Ruimin Long; Maobin Xie; Ranjith Kumar Kankala; Shibin Wang; Yu Shrike Zhang; Yuangang Liu

doi:10.1016/j.bioactmat.2023.04.025

Biomedical applications of magnetosomes: State of the art and perspectives

Bioact Mater. 2023 May 11:28:27-49. doi: 10.1016/j.bioactmat.2023.04.025. eCollection 2023 Oct.

Authors

Gang Ren^{1

2}, Xia Zhou^{1

3}, Ruimin Long³, Maobin Xie^{4

5}, Ranjith Kumar Kankala^{3

6}, Shibin Wang^{1

2

6}, Yu Shrike Zhang⁴, Yuangang Liu^{1

3

6}

Affiliations

¹ Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen, Fujian, 361021, China.
² College of Materials Science and Engineering, Huaqiao University, Xiamen, Fujian, 361021, China.
³ College of Chemical Engineering, Huaqiao University, Xiamen, Fujian, 361021, China.
⁴ Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
⁵ The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436, China.
⁶ Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen, Fujian, 361021, China.

Abstract

Magnetosomes, synthesized by magnetotactic bacteria (MTB), have been used in nano- and biotechnological applications, owing to their unique properties such as superparamagnetism, uniform size distribution, excellent bioavailability, and easily modifiable functional groups. In this review, we first discuss the mechanisms of magnetosome formation and describe various modification methods. Subsequently, we focus on presenting the biomedical advancements of bacterial magnetosomes in biomedical imaging, drug delivery, anticancer therapy, biosensor. Finally, we discuss future applications and challenges. This review summarizes the application of magnetosomes in the biomedical field, highlighting the latest advancements and exploring the future development of magnetosomes.

Keywords: Biomedical applications; Bionic magnetosomes; Magnetosome; Magnetotactic bacteria; Modification strategies.

Publication types

Review