Sparcl1 and Atherosclerosis

Xu Cheng; Xinyan Chen; Min Zhang; Yufeng Wan; Shenglin Ge; Xiaowen Cheng

doi:10.2147/JIR.S406907

Sparcl1 and Atherosclerosis

J Inflamm Res. 2023 May 17:16:2121-2127. doi: 10.2147/JIR.S406907. eCollection 2023.

Authors

Xu Cheng^{1

2}, Xinyan Chen^{2

3}, Min Zhang³, Yufeng Wan⁴, Shenglin Ge¹, Xiaowen Cheng^{2

3

5}

Affiliations

¹ Department of Cardiovascular Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, People's Republic of China.
² Laboratory of Molecular Biology and Department of Biochemistry, Anhui Medical University, Hefei, Anhui, 230022, People's Republic of China.
³ Department of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, People's Republic of China.
⁴ Department of Otolaryngology-Head Neck Surgery, the Affiliated Chaohu Hospital of Anhui Medical University, Hefei, Anhui, 238001, People's Republic of China.
⁵ Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, Anhui, 233030, People's Republic of China.

Abstract

Atherosclerosis and its complications constitute some of the major diseases affecting humans worldwide. A core component of atherogenesis is endothelial cell damage and dysfunction, which also includes factors such as adhesion and proliferation of various cells. Multiple studies have shown that atherosclerosis and cancer share a common pathophysiological process and exhibit a degree of similarity. Sparcl-1 is a cysteine-rich secretory stromal cell protein present in the extracellular matrix and belongs to the Sparc family of proteins. Its role in tumor development has been widely investigated; however, its role in cardiovascular diseases has rarely been studied. Sparcl-1 is considered an oncogene correlated with the regulation of cell adhesion, migration, and proliferation and is also related to blood vessel integrity. In this review, the potential link between Sparcl-1 and atherosclerosis development is investigated, and recommendations on future research on the role of Sparcl-1 in atherogenesis are provided.

Keywords: Sparcl-1; atherogenesis; cancer.

Publication types

Review

Grants and funding

This study was supported by Anhui Medical University Scientific Research Fund (Grant No.2020xkj220 and 2020xkj165), the Natural Science Foundation of the Anhui Higher Education Institutions of China (Grant No.KJ2019A0260), the Key Scientific Research Platform Open Project Fund of Anhui Province (Grant No.KFZZ202204) and Postgraduate Innovation Research and Practice Program of Anhui Medical University (Grant No.YJS20230072).