Post-operative Tumor Lysis Syndrome in High-Grade Uterine Sarcoma

Hana Qasim; Himil J Mahadevia; Ben Ponvilawan; Hana Hamdan; Anuj Shrestha

doi:10.7759/cureus.37956

Post-operative Tumor Lysis Syndrome in High-Grade Uterine Sarcoma

Cureus. 2023 Apr 21;15(4):e37956. doi: 10.7759/cureus.37956. eCollection 2023 Apr.

Authors

Hana Qasim¹, Himil J Mahadevia^{2

1}, Ben Ponvilawan¹, Hana Hamdan³, Anuj Shrestha⁴

Affiliations

¹ Internal Medicine, University of Missouri, Kansas City, USA.
² Internal Medicine, Mayo Clinic, Jacksonville, USA.
³ Pathology, University of Missouri, Kansas City, USA.
⁴ Hematology and Oncology, University of Missiouri, Kansas City, USA.

Abstract

Tumor lysis syndrome (TLS) is a well-known oncologic emergency. It is a constellation of metabolic derangements usually observed in hematological malignancies due to rapid cell lysis, typically due to chemotherapy or radiotherapy initiation. Spontaneous TLS is an unusual complication in solid malignancies, and only a few cases have previously been reported for spontaneous TLS in gynecological malignancies. We report a case of TLS in a 50-year-old female patient shortly after resection of high-grade uterine sarcoma. We review previous TLS cases in uterine malignancies and the associated morbidity and mortality.

Keywords: gynec oncology; post-op; spontaneous tumor lysis without precipitating factor; tumor-lysis syndrome; uterine sarcoma.

Publication types

Case Reports