Over the last years, methods devoted to the synthesis of asymmetric molecules bearing a perfluoroalkylated chain have been limited in number. Among them, only a few can be used on a large variety of scaffolds. This microreview aims at summarizing these recent advances in enantioselective perfluoroalkylation (-CF3 , -CF2 H, -Cn F2n+1 ) and highlights the need for new enantioselective methods to easily synthesize chiral fluorinated molecules which would be useful for the pharmaceutical and agrochemical industries. Some perspectives are also mentioned.
Keywords: Asymmetric catalysis; Enantioselectivity; Fluorine; Perfluoroalkyl chains.
© 2023 The Authors. The Chemical Record published by The Chemical Society of Japan and Wiley-VCH GmbH.