COVID-19 Pneumonia with Migratory Pattern in Agammaglobulinemic Patients: A Report of Two Cases and Review of Literature

Melania Degli Antoni; Verena Crosato; Francesca Pennati; Andrea Borghesi; Graziella Cristini; Roberto Allegri; Susanna Capone; Alberto Bergamasco; Annarosa Soresina; Raffaele Badolato; Roberto Maroldi; Eugenia Quiros-Roldan; Alberto Matteelli; Francesco Castelli; Emanuele Focà

doi:10.3390/tomography9030073

COVID-19 Pneumonia with Migratory Pattern in Agammaglobulinemic Patients: A Report of Two Cases and Review of Literature

Tomography. 2023 Apr 23;9(3):894-900. doi: 10.3390/tomography9030073.

Authors

Affiliations

¹ Unit of Infectious and Tropical Diseases, Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
² Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia and ASST Spedali Civili of Brescia, 25123 Brescia, Italy.
³ Unit of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
⁴ Pediatric Immunology Unit, Ospedale dei Bambini, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
⁵ Molecular Medicine Institute "Angelo Nocivelli", Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.

Abstract

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in serum immunoglobulins and early-onset infections. Coronavirus Disease-2019 (COVID-19) pneumonia in immunocompromised patients presents clinical and radiological peculiarities which have not yet been completely understood. Very few cases of agammaglobulinemic patients with COVID-19 have been reported since the beginning of the pandemic in February 2020. We report two cases of migrant COVID-19 pneumonia in XLA patients.

Keywords: COVID-19; X-linked agammaglobulinemia; computed tomography; migrant pneumonia; organizing pneumonia.

Publication types

Review
Case Reports

MeSH terms

Agammaglobulinemia* / complications
Agammaglobulinemia* / diagnostic imaging
COVID-19* / complications
Genetic Diseases, X-Linked*
Humans
Pneumonia*

Supplementary concepts

Bruton type agammaglobulinemia

Grants and funding

This research received no external funding.