Discovery of novel non-peptidic and non-covalent small-molecule 3CL^pro inhibitors as potential candidate for COVID-19 treatment

Affiliations

• ¹ School of Life Science and Technology, ShanghaiTech University, Shanghai, 201203, China.
• ² Lingang Laboratory, Shanghai, 201203, China.
• ³ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
• ⁴ Shenyang Pharmaceutical University, Shenyang, 110016, China.
• ⁵ State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
• ⁶ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. suhaixia1@simm.ac.cn.
• ⁷ State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China. zhangleike@wh.iov.cn.
• ⁸ School of Life Science and Technology, ShanghaiTech University, Shanghai, 201203, China. yzang@lglab.ac.cn.
• ⁹ Lingang Laboratory, Shanghai, 201203, China. yzang@lglab.ac.cn.
• ¹⁰ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. yzang@lglab.ac.cn.
• ¹¹ School of Life Science and Technology, ShanghaiTech University, Shanghai, 201203, China. zhouyu@simm.ac.cn.
• ¹² Lingang Laboratory, Shanghai, 201203, China. zhouyu@simm.ac.cn.
• ¹³ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. zhouyu@simm.ac.cn.