Prognostic value of ventricle epicardial fat volume by cardiovascular magnetic resonance in chronic heart failure

Iokfai Cheang; Xu Zhu; Xin Yue; Yuan Tang; Yujie Gao; Xinyi Lu; Shi Shi; Shengen Liao; Wenming Yao; Yanli Zhou; Haifeng Zhang; Yinsu Zhu; Yi Xu; Xinli Li

doi:10.1016/j.isci.2023.106755

Prognostic value of ventricle epicardial fat volume by cardiovascular magnetic resonance in chronic heart failure

iScience. 2023 Apr 27;26(5):106755. doi: 10.1016/j.isci.2023.106755. eCollection 2023 May 19.

Authors

Iokfai Cheang¹, Xu Zhu¹, Xin Yue¹, Yuan Tang¹, Yujie Gao², Xinyi Lu¹, Shi Shi¹, Shengen Liao¹, Wenming Yao¹, Yanli Zhou¹, Haifeng Zhang^{1

3}, Yinsu Zhu², Yi Xu², Xinli Li¹

Affiliations

¹ Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.
² Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.
³ Department of Cardiology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215002, China.

Abstract

The purpose of this study is to explore the prognostic values of ventricle epicardial fat volume (EFV) calculated by cardiac magnetic resonance in patients with chronic heart failure (CHF). A total of 516 patients with CHF (left ventricular ejection fraction ≤ 50%) were recruited, and 136 (26.4%) of whom experienced major adverse cardiovascular events (MACE) within median follow-up of 24 months. The target marker-EFV was found to be associated with MACE in both univariate and multivariable analysis adjusted for various clinical variables (p < 0.01), regardless as a continuous variable and categorized by X-tile program. EFV also showed promising predictive ability, with an area under the curve of 0.612, 0.618, and 0.687 for the prediction of 1-year, 2-year, and 3-year MACE, respectively. In conclusion, EFV could be a useful prognostic marker for CHF patients, helping to identify individuals at greater risk of MACE.

Keywords: Clinical finding; Human physiology; Medical tests; Physiology.