Background: Mpox is a zoonotic viral disease transmitted by close contact with infected individuals, contacting or eating infected animals, and now, sexual contact. The main treatment option for infected individuals is supportive care as no FDA-approved treatment exists.
Case presentation: A 33-year-old male with HIV who contracted Mpox who developed a large painful genital ulcer with overlying eschar. He required surgical debridement of the penile ulcer followed by scrotoplasty.
Conclusion: While local wound care plus antibiotics may be effective at managing some genital lesions, Urologists should consider surgical debridement with delayed reconstruction for progressive, non-healing wounds in these individuals.
Keywords: Genital infections; Monkeypox virus; Reconstructive urology.