Cysteinyl Leukotriene and Systemic Inflammatory Levels in Preeclampsia

Gokhan Guzeltas; Mujde Can Ibanoglu; Yaprak Engin-Üstün

doi:10.7759/cureus.37764

Cysteinyl Leukotriene and Systemic Inflammatory Levels in Preeclampsia

Cureus. 2023 Apr 18;15(4):e37764. doi: 10.7759/cureus.37764. eCollection 2023 Apr.

Authors

Gokhan Guzeltas¹, Mujde Can Ibanoglu², Yaprak Engin-Üstün^{3

4}

Affiliations

¹ Obstetrics, University of Health Sciences Ankara City Hospital, Ankara, TUR.
² Obstetrics, Etlik Zubeyde Hanım EAH, Ankara, TUR.
³ Obstetrics and Gynecology, University of Health Sciences Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Ankara, TUR.
⁴ Obstetrics and Gynecology, Zekai Tahir Burak Womens Health Research and Education Hospital, Ankara, TUR.

Abstract

Background In this study, we aimed to demonstrate the efficacy of cysteinyl leukotriene levels, which play a role in inflammation, in predicting the severity of preeclampsia (PE) and to determine whether this marker can be used as a screening tool. Methods In this cross-sectional analytic study, we classified pregnant women who were normotensive (control) or PE or severe PE (SPE) between March 2019 and July 2019. Singleton pregnant 60 women who met the following criteria for the diagnosis of PE were included in the study group. We identified 30 patients with PE and 30 patients with SPE. Normotensive pregnant women (n=30) who met this criterion were included as a control group by randomly selecting them on odd days of the week. Results All pregnant women who participated in the study had a singleton pregnancy, and maternal age ranged from 18 to 40 years, with a mean age of 28.77±6.37 years. The mean gestational week of the group was 35.54±3.247 weeks. Gestational age was higher in women in the control group (p=0.018), shock index was higher in women in the control group (p < 0.001), and body mass index (BMI) value was lower in this group than in the other groups (p=0.002). The values of mean arterial pressure (MAP) were found to have a strong correlation with shock index value and a weak and negative correlation with gestational week and platelet/lymphocyte ratio (p < 0.05). The mean cysteinyl leukotriene levels of 206.15 pg/mL for the control group, 273.2 pg/mL for PE, and 211.85 pg/mL for SPE were calculated. However, no statistically significant difference was found between the groups (p=0.707). Conclusion We found that cysteinyl leukotrienes were not clinically important in assessing the risk for developing PE and predicting SPE. Alanine aminotransferase, white blood cell, lymphocyte, C-reactive protein, platelet/lymphocyte ratio, and shock index were positively correlated with the value of MAP.

Keywords: c-reactive protein; cysteinyl leukotriene; preeclampsia; severe preeclampsia; systematic inflammation.