Therapeutic Application of Cell Secretomes in Cutaneous Wound Healing

Daniel Bormann; Alfred Gugerell; Hendrik Jan Ankersmit; Michael Mildner

doi:10.1016/j.jid.2023.02.019

Therapeutic Application of Cell Secretomes in Cutaneous Wound Healing

J Invest Dermatol. 2023 Jun;143(6):893-912. doi: 10.1016/j.jid.2023.02.019.

Authors

Daniel Bormann¹, Alfred Gugerell¹, Hendrik Jan Ankersmit¹, Michael Mildner²

Affiliations

¹ Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
² Department of Dermatology, Medical University of Vienna, Vienna, Austria. Electronic address: michael.mildner@meduniwien.ac.at.

PMID: 37211377
DOI: 10.1016/j.jid.2023.02.019

Abstract

Although the application of stem cells to chronic wounds emerged as a candidate therapy in the previous century, the mechanism of action remains unclear. Recent evidence has implicated secreted paracrine factors in the regenerative properties of cell-based therapies. In the last two decades, considerable research advances involving the therapeutic potential of stem cell secretomes have expanded the scope of secretome-based therapies beyond stem cell populations. In this study, we review the modes of action of cell secretomes in wound healing, important preconditioning strategies for enhancing their therapeutic efficacy, and clinical trials on secretome-based wound healing.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell- and Tissue-Based Therapy
Secretome*
Stem Cells
Wound Healing*