Advances and Challenges for GWAS Analysis in Cardiac Diseases: A Focus on Coronary Artery Disease (CAD)

Shahid Ullah Khan; Sumbul Saeed; Amnah Mohammed Alsuhaibani; Sumaya Fatima; Khalil Ur Rehman; Umber Zaman; Muneeb Ullah; Moamen S Refat; Kun Lu

doi:10.1016/j.cpcardiol.2023.101821

Advances and Challenges for GWAS Analysis in Cardiac Diseases: A Focus on Coronary Artery Disease (CAD)

Curr Probl Cardiol. 2023 Sep;48(9):101821. doi: 10.1016/j.cpcardiol.2023.101821. Epub 2023 May 19.

Authors

Shahid Ullah Khan¹, Sumbul Saeed², Amnah Mohammed Alsuhaibani³, Sumaya Fatima⁴, Khalil Ur Rehman⁵, Umber Zaman⁵, Muneeb Ullah⁶, Moamen S Refat⁷, Kun Lu⁸

Affiliations

¹ Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, College of Agronomy and Biotechnology, Southwest University, Chongqing, 400715, China; Engineering Research Center of South Upland Agriculture, Ministry of Education, Chongqing, 400715, China; Women Medical and Dental College, Khyber Medical University, Peshawar, KPK, 22020, Pakistan.
² Centre for Cell Factories and Biopolymers (CCFB), Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD, 4111, Australia.
³ Department of Physical Sport Science, College of Education, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
⁴ Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.
⁵ Institute of Chemical Sciences, Gomal University, Dera Ismail Khan, KPK, 29050, Pakistan.
⁶ Department of Pharmacy, Kohat University of Science and Technology, Kohat, KPK, Pakistan.
⁷ Department of Chemistry, College of Science, Taif University, Taif, Saudi Arabia.
⁸ Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, College of Agronomy and Biotechnology, Southwest University, Chongqing, 400715, China; Engineering Research Center of South Upland Agriculture, Ministry of Education, Chongqing, 400715, China. Electronic address: drlukun@swu.edu.cn.

PMID: 37211304
DOI: 10.1016/j.cpcardiol.2023.101821

Abstract

The achievement of genome-wide association studies (GWAS) has rapidly progressed our understanding of the etiology of coronary artery disease (CAD). It unlocks new strategies to strengthen the stalling of CAD drug development. In this review, we highlighted the recent drawbacks, mainly pointing out those involved in identifying causal genes and interpreting the connections between disease pathology and risk variants. We also benchmark the novel insights into the biological mechanism behind the disease primarily based on outcomes of GWAS. Furthermore, we also shed light on the successful discovery of novel treatment targets by introducing various layers of "omics" data and applying systems genetics strategies. Lastly, we discuss in-depth the significance of precision medicine that is helpful to improve through GWAS analysis in cardiovascular research.

Publication types

Review

MeSH terms

Coronary Artery Disease* / genetics
Coronary Artery Disease* / therapy
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Precision Medicine
Risk Factors