Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in a hamster model

Antiviral Res. 2023 Jul:215:105638. doi: 10.1016/j.antiviral.2023.105638. Epub 2023 May 18.

Abstract

The successive emergence of SARS-CoV-2 Omicron variants has completely changed the modalities of use of therapeutic monoclonal antibodies. Recent in vitro studies indicated that only Sotrovimab has maintained partial activity against BQ.1.1 and XBB.1. In the present study, we used the hamster model to determine whether Sotrovimab retains antiviral activity against these Omicron variants in vivo. Our results show that at exposures consistent with those observed in humans, Sotrovimab remains active against BQ.1.1 and XBB.1, although for BQ.1.1 the efficacy is lower than that observed against the first globally dominant Omicron sublineages BA.1 and BA.2.

Keywords: Hamster model; Monoclonal antibody; Omicron variants; SARS-CoV-2; Sotrovimab.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal, Humanized
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • COVID-19*
  • Cricetinae
  • Humans
  • SARS-CoV-2

Substances

  • sotrovimab
  • Antibodies, Monoclonal, Humanized
  • Antibodies, Neutralizing
  • Antibodies, Viral

Supplementary concepts

  • SARS-CoV-2 variants