A Systematic Review and Meta-analysis of Clinical Outcomes in Autologous Breast Reconstruction Using Internal Mammary Artery Perforators as Recipient Vessels

Oscar F Fernandez-Diaz; Georgios Christopoulos; Matthew Griffiths

doi:10.1097/GOX.0000000000004969

A Systematic Review and Meta-analysis of Clinical Outcomes in Autologous Breast Reconstruction Using Internal Mammary Artery Perforators as Recipient Vessels

Plast Reconstr Surg Glob Open. 2023 May 17;11(5):e4969. doi: 10.1097/GOX.0000000000004969. eCollection 2023 May.

Authors

Oscar F Fernandez-Diaz^{1

2}, Georgios Christopoulos^{2

3}, Matthew Griffiths¹

Affiliations

¹ From the St. Andrew's Centre for Plastic Surgery and Burns, Broomfield Hospital, Chelmsford, UK.
² Group for Academic Plastic Surgery, Blizard Institute, Queen Mary University of London, London, UK.
³ Department of Plastic Surgery, Queen Victoria Hospital, East Grinstead, West Sussex, UK.

Abstract

Recipient vessel selection is vital for successful autologous free-flap breast reconstruction. Internal mammary artery perforators have gained interest as a recipient vessel option. However, previous studies on their microsurgical safety and efficacy are limited and inconsistent. Thus, we conducted a systematic review and meta-analysis to assess the safety and effectiveness of using internal mammary artery perforators as recipient vessels in breast reconstruction.

Methods: The protocol has been previously published in PROSPERO (CRD42020190020). The PubMed, Scopus, Web of Science, and PROSPERO databases were searched. Two independent reviewers evaluated the articles for inclusion in the study. Study quality was assessed using the Newcastle-Ottawa Scale and the MINORS instrument (Methodological Index for Non-Randomized Studies).

Results: Of the 361 articles screened, 13 studies were included (313 patients with 318 flaps; 223 unilateral, 31 bilateral, mean average age 51.2 and mean BMI 27.8 ± 1.9). The mean overall success rate was 99.8%, the pooled surgical success rate was 100% [95% confidence interval (CI): 97%-100%], and the overall rate of complications was 11% (95% CI: 7%-18%). The most common complication was vascular-related to microanastomoses, with an incidence of 5% (95% CI: 2%-10%). The fat necrosis rate was 3% (95% CI: 2%-6%).

Conclusions: This study verified that internal mammary artery perforator vessels are reliable in breast reconstruction, with a high success rate and a relatively low complication rate. Moreover, in selected microsurgical breast reconstruction patients, internal mammary artery perforators may be the primary recipient vessel choice over the internal mammary artery or thoracodorsal vessels.